2. Metabolic Enzyme/Protease Vitamin D Related/Nuclear Receptor
  3. LXR
  4. LXRβ agonist-3

LXRβ agonist-3 (compound 4-13) is a potent and selective LXRβ (liver X receptor β) agonist, with an EC50 of 0.095 μM. LXRβ agonist-3 efficiently inhibits U87EGFRvIII cell, with an IC50 of 3.75 μM. LXRβ agonist-3 shows antitumor activity, and can inhibit glioblastoma.

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LXRβ agonist-3 Chemical Structure

LXRβ agonist-3 Chemical Structure

CAS No. : 2413308-63-9

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LXRβ agonist-3 Related Antibodies

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Description

LXRβ agonist-3 (compound 4-13) is a potent and selective LXRβ (liver X receptor β) agonist, with an EC50 of 0.095 μM. LXRβ agonist-3 efficiently inhibits U87EGFRvIII cell, with an IC50 of 3.75 μM. LXRβ agonist-3 shows antitumor activity, and can inhibit glioblastoma[1].

IC50 & Target

EC50: 0.095 ± 0.012 μM (LXRβ) 0.277 ± 0.066 μM (LXRα)[1]
In Vivo

LXRβ agonist-3 (compound 4-13) (BALB/c mice, 50 mg/kg, IP, daily for 15 days) significantly reduces glioblastoma tumor growth[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

563.66

Formula

C30H33N3O6S
CAS No.
SMILES

O=C1[C@@]2(C3=CC=CC=C3N1)C(C4=CC(NC5=CC(S(C)(=O)=O)=C(C=C5)CO)=CC=C4)N(CC2)C(OC(C)(C)C)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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LXRβ agonist-3 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

LXRβ agonist-32413308-63-9LXRβ agonist3LXRβ agonist 3LXRLiver X receptorglioblastoma inhibitorU87EGFRvIII cellantitumor activityNuclear receptorInhibitorinhibitorinhibit

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