2. Epigenetics
  3. Histone Acetyltransferase
  4. Lys-CoA TFA

Lys-CoA TFA is a selective p300 histone acetyltransferase (HAT) inhibitor (IC50=50-500 nM). Lys-CoA TFA displays >100-fold selectivity for p300 over PCAF (IC50=200 μM). Lys-CoA TFA inhibits p300 HAT activity-dependent transcriptional activation.

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Lys-CoA TFA Chemical Structure

Lys-CoA TFA Chemical Structure

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1 mg USD 350 In-stock
5 mg USD 950 In-stock
10 mg USD 1500 In-stock
25 mg USD 3200 In-stock
50 mg USD 5250 In-stock
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Based on 1 publication(s) in Google Scholar

Lys-CoA TFA Related Antibodies

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Description

Lys-CoA TFA is a selective p300 histone acetyltransferase (HAT) inhibitor (IC50=50-500 nM). Lys-CoA TFA displays >100-fold selectivity for p300 over PCAF (IC50=200 μM). Lys-CoA TFA inhibits p300 HAT activity-dependent transcriptional activation[1][2].

IC50 & Target[1]

p300

50-500 nM (IC50)

In Vitro

Lys-CoA TFA (0.1 and 1 mM; 60 hours) induces a senescent phenotype in human normal melanocytes[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Lys-CoA TFA Related Antibodies

Cell Proliferation Assay[3]

Cell Line: Normal human melanocytes
Concentration: 0.1 and 1 mM
Incubation Time: 60 hours
Result: Almost completely abolished proliferation, induced high levels of SA-β-Gal, and inhibited cyclin E expression in a dose-dependent manner.
Molecular Weight

1108.82

Formula

C33H54F3N10O21P3S
Appearance

Solid

Color

White to off-white

SMILES

OC(C(F)(F)F)=O.O[C@H](C(C)(COP(OP(OC[C@@H]1[C@@H](OP(O)(O)=O)[C@@H](O)[C@H](N2C=NC3=C2N=CN=C3N)O1)(O)=O)(O)=O)C)C(NCCC(NCCSCC(NCCCC[C@H](NC(C)=O)C(N)=O)=O)=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

H2O : 70 mg/mL (63.13 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.9019 mL 4.5093 mL 9.0186 mL
5 mM 0.1804 mL 0.9019 mL 1.8037 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

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Volume (start)

V1

=
Concentration (final)

C2

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Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

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(per animal)

g

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(per animal)

μL

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 0.9019 mL 4.5093 mL 9.0186 mL 22.5465 mL
5 mM 0.1804 mL 0.9019 mL 1.8037 mL 4.5093 mL
10 mM 0.0902 mL 0.4509 mL 0.9019 mL 2.2546 mL
15 mM 0.0601 mL 0.3006 mL 0.6012 mL 1.5031 mL
20 mM 0.0451 mL 0.2255 mL 0.4509 mL 1.1273 mL
25 mM 0.0361 mL 0.1804 mL 0.3607 mL 0.9019 mL
30 mM 0.0301 mL 0.1503 mL 0.3006 mL 0.7515 mL
40 mM 0.0225 mL 0.1127 mL 0.2255 mL 0.5637 mL
50 mM 0.0180 mL 0.0902 mL 0.1804 mL 0.4509 mL
60 mM 0.0150 mL 0.0752 mL 0.1503 mL 0.3758 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Lys-CoA TFA Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Lys-CoAHistone AcetyltransferaseHATsHATselectivityp300histoneacetyltransferasetranscriptionalsenescentphenotypeInhibitorinhibitorinhibit

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