2. Antibody-drug Conjugate/ADC Related PROTAC
  3. ADC Linker PROTAC Linkers
  4. m-PEG11-acid

m-PEG11-acid is a non-cleavable 11 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). m-PEG11-acid is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

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m-PEG11-acid Chemical Structure

m-PEG11-acid Chemical Structure

CAS No. : 2280998-74-3

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Based on 1 publication(s) in Google Scholar

m-PEG11-acid Related Antibodies

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Description

m-PEG11-acid is a non-cleavable 11 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1]. m-PEG11-acid is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[2].

IC50 & Target[1][2]

PEGs

 

Non-cleavable Linker

 

In Vitro

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1].
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

m-PEG11-acid Related Antibodies
Molecular Weight

544.63

Formula

C24H48O13
CAS No.
Appearance

Liquid (Density: 1.113±0.06 g/cm3)

Color

Colorless to light yellow

SMILES

OC(CCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOC)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, protect from light, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (183.61 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.8361 mL 9.1805 mL 18.3611 mL
5 mM 0.3672 mL 1.8361 mL 3.6722 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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C2

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In Vivo Dissolution Calculator
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.8361 mL 9.1805 mL 18.3611 mL 45.9027 mL
5 mM 0.3672 mL 1.8361 mL 3.6722 mL 9.1805 mL
10 mM 0.1836 mL 0.9181 mL 1.8361 mL 4.5903 mL
15 mM 0.1224 mL 0.6120 mL 1.2241 mL 3.0602 mL
20 mM 0.0918 mL 0.4590 mL 0.9181 mL 2.2951 mL
25 mM 0.0734 mL 0.3672 mL 0.7344 mL 1.8361 mL
30 mM 0.0612 mL 0.3060 mL 0.6120 mL 1.5301 mL
40 mM 0.0459 mL 0.2295 mL 0.4590 mL 1.1476 mL
50 mM 0.0367 mL 0.1836 mL 0.3672 mL 0.9181 mL
60 mM 0.0306 mL 0.1530 mL 0.3060 mL 0.7650 mL
80 mM 0.0230 mL 0.1148 mL 0.2295 mL 0.5738 mL
100 mM 0.0184 mL 0.0918 mL 0.1836 mL 0.4590 mL
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m-PEG11-acid Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

m-PEG11-acid2280998-74-3ADC LinkerPROTAC LinkersAntibody-drug conjugates linkerPEGADCnon-cleavablelinkerPROTACInhibitorinhibitorinhibit

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