2. PROTAC
  3. PROTAC Linkers
  4. m-PEG12-acid

m-PEG12-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

For research use only. We do not sell to patients.

m-PEG12-acid Chemical Structure

m-PEG12-acid Chemical Structure

CAS No. : 2135793-73-4

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Based on 1 publication(s) in Google Scholar

m-PEG12-acid Related Antibodies

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PEG Linkers Alkyl-Chain Linkers Alkyl/ether Linkers

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Description

m-PEG12-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

IC50 & Target

PEGs

 

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

m-PEG12-acid Related Antibodies
Molecular Weight

588.68

Formula

C26H52O14
CAS No.
Appearance

Solid-Liquid Mixture

Color

White to light yellow

SMILES

COCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCC(O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Pure form -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (169.87 mM; ultrasonic and warming and heat to 54°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.6987 mL 8.4936 mL 16.9872 mL
5 mM 0.3397 mL 1.6987 mL 3.3974 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.12%

SDS (393 KB)

COA (248 KB) HNMR (236 KB) RP-HPLC (181 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.6987 mL 8.4936 mL 16.9872 mL 42.4679 mL
5 mM 0.3397 mL 1.6987 mL 3.3974 mL 8.4936 mL
10 mM 0.1699 mL 0.8494 mL 1.6987 mL 4.2468 mL
15 mM 0.1132 mL 0.5662 mL 1.1325 mL 2.8312 mL
20 mM 0.0849 mL 0.4247 mL 0.8494 mL 2.1234 mL
25 mM 0.0679 mL 0.3397 mL 0.6795 mL 1.6987 mL
30 mM 0.0566 mL 0.2831 mL 0.5662 mL 1.4156 mL
40 mM 0.0425 mL 0.2123 mL 0.4247 mL 1.0617 mL
50 mM 0.0340 mL 0.1699 mL 0.3397 mL 0.8494 mL
60 mM 0.0283 mL 0.1416 mL 0.2831 mL 0.7078 mL
80 mM 0.0212 mL 0.1062 mL 0.2123 mL 0.5308 mL
100 mM 0.0170 mL 0.0849 mL 0.1699 mL 0.4247 mL
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m-PEG12-acid Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

m-PEG12-acid2135793-73-4PROTAC LinkersInhibitorinhibitorinhibit

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