2. PROTAC
  3. PROTAC Linkers
  4. m-PEG4-PFP ester

m-PEG4-PFP ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

For research use only. We do not sell to patients.

m-PEG4-PFP ester Chemical Structure

m-PEG4-PFP ester Chemical Structure

CAS No. : 2952895-31-5

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50 mg USD 80 In-stock
100 mg USD 130 In-stock
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Based on 1 publication(s) in Google Scholar

m-PEG4-PFP ester Related Antibodies

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Description

m-PEG4-PFP ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

IC50 & Target

PEGs

 

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

m-PEG4-PFP ester Related Antibodies
Molecular Weight

402.31

Formula

C16H19F5O6
CAS No.
Appearance

Liquid (Density: 1.316±0.06 g/cm3)

Color

Colorless to light yellow

SMILES

COCCOCCOCCOCCC(OC1=C(F)C(F)=C(F)C(F)=C1F)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Pure form -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 100 mg/mL (248.56 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.4856 mL 12.4282 mL 24.8565 mL
5 mM 0.4971 mL 2.4856 mL 4.9713 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

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g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: ≥98.0%

COA (242 KB) HNMR (295 KB) MS (71 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.4856 mL 12.4282 mL 24.8565 mL 62.1411 mL
5 mM 0.4971 mL 2.4856 mL 4.9713 mL 12.4282 mL
10 mM 0.2486 mL 1.2428 mL 2.4856 mL 6.2141 mL
15 mM 0.1657 mL 0.8285 mL 1.6571 mL 4.1427 mL
20 mM 0.1243 mL 0.6214 mL 1.2428 mL 3.1071 mL
25 mM 0.0994 mL 0.4971 mL 0.9943 mL 2.4856 mL
30 mM 0.0829 mL 0.4143 mL 0.8285 mL 2.0714 mL
40 mM 0.0621 mL 0.3107 mL 0.6214 mL 1.5535 mL
50 mM 0.0497 mL 0.2486 mL 0.4971 mL 1.2428 mL
60 mM 0.0414 mL 0.2071 mL 0.4143 mL 1.0357 mL
80 mM 0.0311 mL 0.1554 mL 0.3107 mL 0.7768 mL
100 mM 0.0249 mL 0.1243 mL 0.2486 mL 0.6214 mL
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m-PEG4-PFP ester Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

m-PEG4-PFP ester2952895-31-5PROTAC LinkersInhibitorinhibitorinhibit

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