M122

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M122 is a potent inhibitor of HDAC1 and HDAC2, with the IC₅₀ values of 0.48 μM and 0.47 μM, respectively, respectively. M122 has antitumor activity.

For research use only. We do not sell to patients.

M122 Chemical Structure

CAS No. : 2127411-50-9

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HDAC HDAC1 HDAC2 HDAC3 HDAC4 HDAC5 HDAC6 HDAC7 HDAC8 HDAC9 HDAC10 HDAC11 HD1 HD2

Biological Activity
Purity & Documentation
References
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Description

M122 is a potent inhibitor of HDAC1 and HDAC2, with the IC₅₀ values of 0.48 μM and 0.47 μM, respectively, respectively. M122 has antitumor activity^[1].

IC₅₀ & Target

HDAC1

0.48 μM (IC₅₀)

hHDAC2

0.47 μM (IC₅₀)

Cellular Effect

Cell Line	Type	Value	Description	References
A-375	IC₅₀	1.27 μM Compound: M122	Antiproliferative activity against human A375 cells after 72 hrs by CCK-8 assay Antiproliferative activity against human A375 cells after 72 hrs by CCK-8 assay	[PMID: 29202397]
HCT-116	IC₅₀	0.54 μM Compound: M122	Antiproliferative activity against human HCT116 cells after 72 hrs by CCK-8 assay Antiproliferative activity against human HCT116 cells after 72 hrs by CCK-8 assay	[PMID: 29202397]
HeLa	IC₅₀	0.79 μM Compound: M122	Antiproliferative activity against human HeLa cells after 72 hrs by CCK-8 assay Antiproliferative activity against human HeLa cells after 72 hrs by CCK-8 assay	[PMID: 29202397]
MGC-803	IC₅₀	1.58 μM Compound: M122	Antiproliferative activity against human MGC803 cells after 72 hrs by CCK-8 assay Antiproliferative activity against human MGC803 cells after 72 hrs by CCK-8 assay	[PMID: 29202397]
NCI-H1299	IC₅₀	2.49 μM Compound: M122	Antiproliferative activity against human NCI-H1299 cells after 72 hrs by CCK-8 assay Antiproliferative activity against human NCI-H1299 cells after 72 hrs by CCK-8 assay	[PMID: 29202397]
SMMC-7721	IC₅₀	1.34 μM Compound: M122	Antiproliferative activity against human SMMC7721 cells after 72 hrs by CCK-8 assay Antiproliferative activity against human SMMC7721 cells after 72 hrs by CCK-8 assay	[PMID: 29202397]

Molecular Weight

463.62

Formula

C₂₄H₂₅N₅OS₂

CAS No.

2127411-50-9

SMILES

S=C(N1CCN(C2=CC=NC=C2)CC1)SCC3=CC=C(C(NC4=CC=CC=C4N)=O)C=C3

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Rui Xie, et al. Design, synthesis and biological evaluation of novel 2-aminobenzamides containing dithiocarbamate moiety as histone deacetylase inhibitors and potent antitumor agents. Eur J Med Chem. 2018 Jan 1:143:320-333. [Content Brief]

M122 Related Classifications

Molarity Calculator
Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass		Concentration		Volume		Molecular Weight *
	=		×		×

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

M1222127411-50-9M 122M-122HDACHistone deacetylasesInhibitorinhibitorinhibit

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M122

M122 Related Antibodies

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Biological Activity

Purity & Documentation

References

Customer Review

M122 Related Classifications

Molarity Calculator

Dilution Calculator