2. GPCR/G Protein Metabolic Enzyme/Protease Neuronal Signaling
  3. Phosphodiesterase (PDE) mAChR
  4. M3/PDE4 modulator-1

M3/PDE4 modulator-1 (compound 10f) is a bifunctional molecule that is an M3 mAChR antagonist and a PDE4 inhibitor. M3/PDE4 modulator-1 (10-1000 nM/kg; iv) reduces cysteine eosinophil influx in the OVA rat model.

For research use only. We do not sell to patients.

M3/PDE4 modulator-1 Chemical Structure

M3/PDE4 modulator-1 Chemical Structure

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M3/PDE4 modulator-1 Related Antibodies

Top Publications Citing Use of Products

View All Phosphodiesterase (PDE) Isoform Specific Products:

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PDE1 PDE2 PDE3 PDE4 PDE5 PDE6 PDE7 PDE9 PDE10 PDE11 PDE12 PDE8 Autotaxin

View All mAChR Isoform Specific Products:

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mAChR1 mAChR2 mAChR3 mAChR4 mAChR5

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Description

M3/PDE4 modulator-1 (compound 10f) is a bifunctional molecule that is an M3 mAChR antagonist and a PDE4 inhibitor. M3/PDE4 modulator-1 (10-1000 nM/kg; iv) reduces cysteine eosinophil influx in the OVA rat model[1].

IC50 & Target

M3 mAChR, PDE4[1]
Molecular Weight

770.72

Formula

C38H41Cl2N3O8S
SMILES

COC1=C(OCC)C=C([C@@H](OC(C2=CC=C(CN[C@](C(O[C@H]3CN4CCC3CC4)=O)(CO)C5=CC=CC=C5)S2)=O)CC6=C(Cl)C=[N+]([O-])C=C6Cl)C=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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M3/PDE4 modulator-1 Related Classifications

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

M3/PDE4 modulator-1Phosphodiesterase (PDE)mAChRMuscarinic acetylcholine receptorMAPIBALF eosinophilActive pharmaceutical ingredientInhibitorinhibitorinhibit

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