2. TGF-beta/Smad
  3. TGF-β Receptor
  4. M4K2281

M4K2281 is a selecitve inhibitor for activin receptor-like kinase-2 (ALK2) with an IC50 of 2 nM. M4K2281 exhibits a moderate blood brain permeability with a brain to plasma ratio of 3.7 at 4h.

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M4K2281 Chemical Structure

M4K2281 Chemical Structure

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M4K2281 Related Antibodies

Top Publications Citing Use of Products

View All TGF-β Receptor Isoform Specific Products:

View All Isoforms
ALK1 ALK2 ALK3 ALK4 ALK5 ALK6 ALK7 TGFβR2 ACVR2A ACVR2B

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Description

M4K2281 is a selecitve inhibitor for activin receptor-like kinase-2 (ALK2) with an IC50 of 2 nM. M4K2281 exhibits a moderate blood brain permeability with a brain to plasma ratio of 3.7 at 4h[1].

IC50 & Target

ALK2

2 nM (IC50)

ALK5

350 nM (IC50)

In Vivo

M4K2281 (25 mg/kg, p.o., single dose) exhibits a exposure in plasma concentration Cmax of 5053 and 0 nM, at 1 hour and 24 hour in NOD-SCID mice model, respectively[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

461.55

Formula

C27H31N3O4
SMILES

CN1CCN(CC1)C2=CC=C3C(OCCC4=C3C=NC=C4C5=CC(OC)=C(C(OC)=C5)OC)=C2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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M4K2281 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

M4K2281TGF-β ReceptorTransforming growth factor beta receptorsintrinsic pontine gliomablood brain barrierInhibitorinhibitorinhibit

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