2. TGF-beta/Smad
  3. TGF-β Receptor
  4. M4K2306

M4K2306 is a selective inhibitor for activin receptor-like kinase-2 (ALK2) with an IC50 of 7 nM. M4K2306 is blood brain permeable with a brain to plasma ratio of 75.6.

For research use only. We do not sell to patients.

M4K2306 Chemical Structure

M4K2306 Chemical Structure

CAS No. : 3034840-25-7

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M4K2306 Related Antibodies

Top Publications Citing Use of Products

View All TGF-β Receptor Isoform Specific Products:

View All Isoforms
ALK1 ALK2 ALK3 ALK4 ALK5 ALK6 ALK7 TGFβR2 ACVR2A ACVR2B

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Description

M4K2306 is a selective inhibitor for activin receptor-like kinase-2 (ALK2) with an IC50 of 7 nM. M4K2306 is blood brain permeable with a brain to plasma ratio of 75.6[1].

IC50 & Target

ALK2

7 nM (IC50)

ALK5

3915 nM (IC50)

In Vivo

M4K2306 (25 mg/kg, po, single dose) exhibits exposure in plasma concentration Cmax of 254 and 17 mM, at 1 hour and 24 hour in NOD-SCID mice model, respectively[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

474.59

Formula

C28H34N4O3
CAS No.
SMILES

CN1CC(C(C2=CC(OC)=C(C(OC)=C2)OC)=CN=C3)=C3C4=CC=C(N5CCN(CC5)C)C=C4C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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M4K2306 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

M4K23063034840-25-7TGF-β ReceptorTransforming growth factor beta receptorsintrinsic pontine gliomablood brain barrierInhibitorinhibitorinhibit

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