mAChR-IN-1

Cat. No.: HY-12426: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

mAChR-IN-1 is a potent muscarinic cholinergic receptor (mAChR) antagonist, with an IC₅₀ of 17 nM.

For research use only. We do not sell to patients.

mAChR-IN-1 Chemical Structure

CAS No. : 119391-56-9

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This product is a controlled substance and not for sale in your territory.

Other In-stock Forms of mAChR-IN-1:

mAChR-IN-1 hydrochloride

Other Forms of mAChR-IN-1:

mAChR-IN-1 hydrochloride In-stock

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•Related Small Molecules:

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View All Isoforms

mAChR1 mAChR2 mAChR3 mAChR4 mAChR5

Biological Activity
Purity & Documentation
References
Customer Review

Description

mAChR-IN-1 is a potent muscarinic cholinergic receptor (mAChR) antagonist, with an IC₅₀ of 17 nM^[1].

Molecular Weight

488.36

Formula

C₂₃H₂₅IN₂O₂

CAS No.

119391-56-9

Appearance

Solid

Color

White to off-white

SMILES

O=C(C(C1CCN(CC2=CC=C(I)C=C2)CC1)(C3=CC=CC=C3)CC4)NC4=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	2 years
	-20°C	1 year

Solvent & Solubility

In Vitro:

DMSO : ≥ 52 mg/mL (106.48 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.0477 mL	10.2383 mL	20.4767 mL
5 mM	0.4095 mL	2.0477 mL	4.0953 mL
10 mM	0.2048 mL	1.0238 mL	2.0477 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.78%

Select Batch:

Data Sheet (274 KB) SDS (252 KB)

COA (257 KB) HNMR (201 KB) LCMS (375 KB)

Handling Instructions (2659 KB)

References

[1]. Wilson AA, et al. Synthesis and biological evaluation of [125I]- and [123I]-4-iododexetimide, a potent muscarinic cholinergic receptor antagonist. J Med Chem. 1989 May;32(5):1057-62. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.0477 mL	10.2383 mL	20.4767 mL	51.1917 mL
	5 mM	0.4095 mL	2.0477 mL	4.0953 mL	10.2383 mL
	10 mM	0.2048 mL	1.0238 mL	2.0477 mL	5.1192 mL
	15 mM	0.1365 mL	0.6826 mL	1.3651 mL	3.4128 mL
	20 mM	0.1024 mL	0.5119 mL	1.0238 mL	2.5596 mL
	25 mM	0.0819 mL	0.4095 mL	0.8191 mL	2.0477 mL
	30 mM	0.0683 mL	0.3413 mL	0.6826 mL	1.7064 mL
	40 mM	0.0512 mL	0.2560 mL	0.5119 mL	1.2798 mL
	50 mM	0.0410 mL	0.2048 mL	0.4095 mL	1.0238 mL
	60 mM	0.0341 mL	0.1706 mL	0.3413 mL	0.8532 mL
	80 mM	0.0256 mL	0.1280 mL	0.2560 mL	0.6399 mL
	100 mM	0.0205 mL	0.1024 mL	0.2048 mL	0.5119 mL

mAChR-IN-1 Related Classifications

Neurological Disease

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

mAChR-IN-1119391-56-9mAChRMuscarinic acetylcholine receptorInhibitorinhibitorinhibit

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