2. Apoptosis Immunology/Inflammation
  3. Caspase NOD-like Receptor (NLR)
  4. Magnesium isoglycyrrhizinate hydrate

Magnesium isoglycyrrhizinate hydrate 

Cat. No.: HY-154795 Purity: 99.81%
COA Handling Instructions

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Magnesium isoglycyrrhizinate hydrate is the active component found in licorice plant (Glycyrrhiza glabra). Magnesium isoglycyrrhizinate hydrate exhibits anti-inflammatory activity through NLRP3 inflammasome pathway, and attenuates the chronic obstructive pulmonary disease in rats.

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Magnesium isoglycyrrhizinate hydrate Chemical Structure

Magnesium isoglycyrrhizinate hydrate Chemical Structure

CAS No. : 658701-67-8

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1 mg USD 35 In-stock
5 mg USD 75 In-stock
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Other Forms of Magnesium isoglycyrrhizinate hydrate:

Magnesium isoglycyrrhizinate hydrate Related Antibodies

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Description

Magnesium isoglycyrrhizinate hydrate is the active component found in licorice plant (Glycyrrhiza glabra). Magnesium isoglycyrrhizinate hydrate exhibits anti-inflammatory activity through NLRP3 inflammasome pathway, and attenuates the chronic obstructive pulmonary disease in rats[1].

IC50 & Target

Caspase-1

 

Molecular Weight

917.28

Formula

C42H68MgO20
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

C[C@]12[C@@](C(C=C3[C@]2(CC[C@@]4([C@]3([H])C[C@](C)(CC4)C(O)=O)C)C)=O)([H])[C@@]5([C@@](C(C)([C@H](CC5)O[C@@H]6[C@@H]([C@H]([C@@H]([C@H](O6)C([O-])=O)O)O)O[C@@H]7O[C@@H]([C@H]([C@@H]([C@H]7O)O)O)C([O-])=O)C)([H])CC1)C.[Mg+2].O.O.O.O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

H2O : 33.33 mg/mL (36.34 mM; adjust pH to 9 with NH3·H2O)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.0902 mL 5.4509 mL 10.9018 mL
5 mM 0.2180 mL 1.0902 mL 2.1804 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

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Volume (start)

V1

=
Concentration (final)

C2

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Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

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g

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(per animal)

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Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation

Purity: 99.81%

COA (264 KB) HNMR (309 KB) LCMS (94 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 1.0902 mL 5.4509 mL 10.9018 mL 27.2545 mL
5 mM 0.2180 mL 1.0902 mL 2.1804 mL 5.4509 mL
10 mM 0.1090 mL 0.5451 mL 1.0902 mL 2.7254 mL
15 mM 0.0727 mL 0.3634 mL 0.7268 mL 1.8170 mL
20 mM 0.0545 mL 0.2725 mL 0.5451 mL 1.3627 mL
25 mM 0.0436 mL 0.2180 mL 0.4361 mL 1.0902 mL
30 mM 0.0363 mL 0.1817 mL 0.3634 mL 0.9085 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Magnesium isoglycyrrhizinate hydrate Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Magnesium isoglycyrrhizinate658701-67-8 CaspaseNOD-like Receptor (NLR)chronic obstructive pulmonary diseaseCOPDlicorice plantGlycyrrhiza glabraWistar ratsInhibitorinhibitorinhibit

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