Mal-amido-PEG2-Val-Cit-PAB-PNP

Name: Mal-amido-PEG2-Val-Cit-PAB-PNP
Brand: MedChemExpress
SKU: HY-140147
Rating: 4.5 (1 reviews)

Cat. No.: HY-140147 Purity: 98.40%: FAQs
Data Sheet SDS COA Handling Instructions

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Mal-amido-PEG2-Val-Cit-PAB-PNP is a cleavable 2 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

For research use only. We do not sell to patients.

Mal-amido-PEG2-Val-Cit-PAB-PNP Chemical Structure

CAS No. : 2112738-13-1

Size	Price	Stock	Quantity
25 mg	USD 340	In-stock	Estimated Time of Arrival: December 31
50 mg	USD 540	In-stock	Estimated Time of Arrival: December 31
100 mg	USD 890	In-stock	Estimated Time of Arrival: December 31
200 mg		Get quote
500 mg		Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

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Biological Activity
Purity & Documentation
References
Customer Review

Description

Mal-amido-PEG2-Val-Cit-PAB-PNP is a cleavable 2 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)^[1].

IC₅₀ & Target

Protease Cleavable Linker

Cleavable Linker

In Vitro

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

854.86

Formula

C₃₉H₅₀N₈O₁₄

CAS No.

2112738-13-1

Appearance

Solid

Color

White to off-white

SMILES

O=C(NC1=CC=C(COC(OC2=CC=C(N(=O)=O)C=C2)=O)C=C1)[C@H](CCCNC(N)=O)NC([C@H](C(C)C)NC(CCOCCOCCNC(CCN(C3=O)C(C=C3)=O)=O)=O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 250 mg/mL (292.45 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.1698 mL	5.8489 mL	11.6978 mL
5 mM	0.2340 mL	1.1698 mL	2.3396 mL
10 mM	0.1170 mL	0.5849 mL	1.1698 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

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μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 98.40%

Select Batch:

Data Sheet (269 KB) SDS (393 KB)

COA (246 KB) HNMR (308 KB) RP-HPLC (247 KB) MS (69 KB)

Handling Instructions (2659 KB)

References

[1]. Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16(5):315-337. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.1698 mL	5.8489 mL	11.6978 mL	29.2446 mL
	5 mM	0.2340 mL	1.1698 mL	2.3396 mL	5.8489 mL
	10 mM	0.1170 mL	0.5849 mL	1.1698 mL	2.9245 mL
	15 mM	0.0780 mL	0.3899 mL	0.7799 mL	1.9496 mL
	20 mM	0.0585 mL	0.2924 mL	0.5849 mL	1.4622 mL
	25 mM	0.0468 mL	0.2340 mL	0.4679 mL	1.1698 mL
	30 mM	0.0390 mL	0.1950 mL	0.3899 mL	0.9748 mL
	40 mM	0.0292 mL	0.1462 mL	0.2924 mL	0.7311 mL
	50 mM	0.0234 mL	0.1170 mL	0.2340 mL	0.5849 mL
	60 mM	0.0195 mL	0.0975 mL	0.1950 mL	0.4874 mL
	80 mM	0.0146 mL	0.0731 mL	0.1462 mL	0.3656 mL
	100 mM	0.0117 mL	0.0585 mL	0.1170 mL	0.2924 mL