2. Antibody-drug Conjugate/ADC Related
  3. ADC Linker
  4. Mal-L-PA-NH-Boc

Mal-L-PA-NH-Boc  (Synonyms: mDPR(boc); (S)-MALEOYL-DPR(BOC)-OH·DCHA)

Cat. No.: HY-41919 Purity: 99.30%
COA Handling Instructions

Molarity Calculator

Mal-L-PA-NH-Boc is a noncleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

For research use only. We do not sell to patients.

Mal-L-PA-NH-Boc Chemical Structure

Mal-L-PA-NH-Boc Chemical Structure

CAS No. : 1491152-23-8

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50 mg USD 90 In-stock
100 mg USD 137 In-stock
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Based on 1 publication(s) in Google Scholar

Mal-L-PA-NH-Boc Related Antibodies

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Description

Mal-L-PA-NH-Boc is a noncleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

IC50 & Target

Non-cleavable Linker

 

Molecular Weight

284.27

Formula

C12H16N2O6
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(C=C1)N([C@@H](CNC(OC(C)(C)C)=O)C(O)=O)C1=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (351.78 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.5178 mL 17.5889 mL 35.1778 mL
5 mM 0.7036 mL 3.5178 mL 7.0356 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.30%

COA (254 KB) HNMR (135 KB) LCMS (88 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.5178 mL 17.5889 mL 35.1778 mL 87.9446 mL
5 mM 0.7036 mL 3.5178 mL 7.0356 mL 17.5889 mL
10 mM 0.3518 mL 1.7589 mL 3.5178 mL 8.7945 mL
15 mM 0.2345 mL 1.1726 mL 2.3452 mL 5.8630 mL
20 mM 0.1759 mL 0.8794 mL 1.7589 mL 4.3972 mL
25 mM 0.1407 mL 0.7036 mL 1.4071 mL 3.5178 mL
30 mM 0.1173 mL 0.5863 mL 1.1726 mL 2.9315 mL
40 mM 0.0879 mL 0.4397 mL 0.8794 mL 2.1986 mL
50 mM 0.0704 mL 0.3518 mL 0.7036 mL 1.7589 mL
60 mM 0.0586 mL 0.2931 mL 0.5863 mL 1.4657 mL
80 mM 0.0440 mL 0.2199 mL 0.4397 mL 1.0993 mL
100 mM 0.0352 mL 0.1759 mL 0.3518 mL 0.8794 mL
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Mal-L-PA-NH-Boc Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Mal-L-PA-NH-Boc1491152-23-8mDPR(boc) (S)-MALEOYL-DPR(BOC)-OH·DCHAADC LinkerAntibody-drug conjugates linkerInhibitorinhibitorinhibit

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