2. PROTAC
  3. PROTAC Linkers
  4. Mal-NH2 TFA

Mal-NH2 (TFA) is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs.

For research use only. We do not sell to patients.

Mal-NH2 TFA Chemical Structure

Mal-NH2 TFA Chemical Structure

CAS No. : 146474-00-2

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Based on 1 publication(s) in Google Scholar

Mal-NH2 TFA Related Antibodies

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Description

Mal-NH2 (TFA) is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1].

IC50 & Target

Alkyl-Chain

 

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Mal-NH2 TFA Related Antibodies
Molecular Weight

254.16

Formula

C8H9F3N2O4
CAS No.
Appearance

Solid

Color

White to light yellow

SMILES

O=C(C=C1)N(CCN)C1=O.O=C(O)C(F)(F)F
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Purity & Documentation

Purity: ≥97.0%

SDS (393 KB)

COA (250 KB) HNMR (120 KB)

Handling Instructions (2659 KB)
References
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Mal-NH2 TFA Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Mal-NH2146474-00-2PROTAC LinkersInhibitorinhibitorinhibit

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Mal-NH2 TFA
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HY-140988
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SAFETY DATA SHEET (SDS)

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