Mal-PEG4-VCP-NB

Cat. No.: HY-160981: FAQs
Data Sheet Handling Instructions

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Mal-PEG4-VCP-NB (Compound 17) is a degradable ADC linker containing a maleimide group, 4 PEG units and VCP NB.

For research use only. We do not sell to patients.

Mal-PEG4-VCP-NB Chemical Structure

CAS No. : 1345681-54-0

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Description

Mal-PEG4-VCP-NB (Compound 17) is a degradable ADC linker containing a maleimide group, 4 PEG units and VCP NB^[1].

IC₅₀ & Target^[1]

Cleavable Linker

Protease Cleavable Linker

Molecular Weight

843.83

Formula

C₃₈H₄₉N₇O₁₅

CAS No.

1345681-54-0

SMILES

O=C(C=CC1=O)N1CCOCCOCCOCCOC(N[C@@H](C(C)C)C(N[C@@H](CCCNC(N)=O)C(NC2=CC=C(C=C2)COC(OC3=CC=C(C=C3)[N+]([O-])=O)=O)=O)=O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Beusker P H, et al. Novel conjugates of CC-1065 analogs and bifunctional linkers[P]. 2011-10-27.

Mal-PEG4-VCP-NB Related Classifications

Molarity Calculator
Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass		Concentration		Volume		Molecular Weight *
	=		×		×

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Mal-PEG4-VCP-NB1345681-54-0ADC LinkerAntibody-drug conjugates linkerInhibitorinhibitorinhibit

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