Mal-Val-Ala-PAB(C2-glucuronic acid)-DMEA-PNU-159682

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Mal-Val-Ala-PAB(C2-glucuronic acid)-DMEA-PNU-159682 is an active molecule-conjugate for ADCs, composed of a cleavable Val-Ala linker and the potent ADC cytotoxic payload PNU-159682 (HY-16700).

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Mal-Val-Ala-PAB(C2-glucuronic acid)-DMEA-PNU-159682 Chemical Structure

CAS No. : 2682939-53-1

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Description	Mal-Val-Ala-PAB(C2-glucuronic acid)-DMEA-PNU-159682 is an active molecule-conjugate for ADCs, composed of a cleavable Val-Ala linker and the potent ADC cytotoxic payload PNU-159682 (HY-16700)^[1].
Molecular Weight	1416.39
Formula	C₆₇H₈₁N₇O₂₇
CAS No.	2682939-53-1
SMILES	OC1=C2C(C(C(C(OC)=CC=C3)=C3C2=O)=O)=C(O)C4=C1C[C@](C(COC(N(C)CCN(C)C(OCC5=CC=C(NC([C@H](C)NC([C@H](C(C)C)NC(CN6C(C=CC6=O)=O)=O)=O)=O)C=C5CC[C@H]7[C@H](O)[C@@H](O)[C@H](O)[C@@H](C(O)=O)O7)=O)=O)=O)(O)C[C@@H]4O[C@H]8C[C@H](N(CCO[C@@H]9OC)[C@@H]9O%10)[C@H]%10[C@H](C)O8
Shipping	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation	Data Sheet (268 KB) Handling Instructions (2659 KB)
References	[1]. Holte D, et al. Evaluation of PNU-159682 antibody drug conjugates (ADCs). Bioorg Med Chem Lett. 2020 Dec 15;30(24):127640. [Content Brief]