2. Anti-infection Apoptosis Autophagy Immunology/Inflammation NF-κB Metabolic Enzyme/Protease
  3. Parasite Apoptosis Autophagy Reactive Oxygen Species
  4. Mammea A/BA

Mammea A/BA has potent activity against Trypanosoma cruzi (T. cruzi). Mammea A/BA induces mitochondrial dysfunction, reactive oxygen species (ROS) production and DNA fragmentation, and increases number of acidic vacuoles. Mammea A/BA can induce apoptosis, autophagy and necrosis. Mammea A/BA can be used for researching chagas disease.

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Mammea A/BA Chemical Structure

Mammea A/BA Chemical Structure

CAS No. : 5224-54-4

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Mammea A/BA Related Antibodies

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Amebae Coccidia Leishmania Mite Plasmodium Toxoplasma Trypanosoma Schistosome

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Description

Mammea A/BA has potent activity against Trypanosoma cruzi (T. cruzi). Mammea A/BA induces mitochondrial dysfunction, reactive oxygen species (ROS) production and DNA fragmentation, and increases number of acidic vacuoles. Mammea A/BA can induce apoptosis, autophagy and necrosis. Mammea A/BA can be used for researching chagas disease[1].

IC50 & Target

T. cruzi[1]
Cellular Effect
Cell Line Type Value Description References
PC-3 IC50
2.18 μM
Compound: 13
Antiproliferative activity against human PC3 cells after 48 hrs
Antiproliferative activity against human PC3 cells after 48 hrs
[PMID: 21214226]
T47D IC50
1.57 μM
Compound: 13
Antiproliferative activity against human T47D cells after 48 hrs
Antiproliferative activity against human T47D cells after 48 hrs
[PMID: 21214226]
T47D IC50
3.23 μM
Compound: 13
Inhibition of hypoxia-induced HIF1 activation in human T47D cells expressing pGL3 construct after 16 hrs by cell-based luciferase reporter assay
Inhibition of hypoxia-induced HIF1 activation in human T47D cells expressing pGL3 construct after 16 hrs by cell-based luciferase reporter assay
[PMID: 21214226]
T47D IC50
3.73 μM
Compound: 13
Inhibition of 1,10-phenanthrolin-induced HIF1 activation in human T47D cells expressing pGL3 construct after 16 hrs by cell-based luciferase reporter assay
Inhibition of 1,10-phenanthrolin-induced HIF1 activation in human T47D cells expressing pGL3 construct after 16 hrs by cell-based luciferase reporter assay
[PMID: 21214226]
Molecular Weight

406.47

Formula

C25H26O5
CAS No.
SMILES

O=C1C=C(C2=CC=CC=C2)C3=C(O)C(C/C=C(C)\C)=C(O)C(C(CC(C)C)=O)=C3O1
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Mammea A/BA Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Mammea A/BA5224-54-4ParasiteApoptosisAutophagyReactive Oxygen SpeciesT. cruzichagas diseaseInhibitorinhibitorinhibit

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