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  5. Saururus chinensis (Lour.) Baill.
  6. Manassantin B

Manassantin B  (Synonyms: (-)-Manassantin B)

Cat. No.: HY-N8225 Purity: 99.29%
SDS COA Handling Instructions Technical Support

Manassantin B (compound 6) is a kind of lignan. Manassantin B can be isolated from the ethyl acetate extract of the roots of Saururus chinensis. Manassantin B has cytotoxicities against HT-29 with an IC50 value of 12 μM.

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Manassantin B Chemical Structure

Manassantin B Chemical Structure

CAS No. : 88497-88-5

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Based on 1 publication(s) in Google Scholar

Manassantin B Related Antibodies

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Description

Manassantin B (compound 6) is a kind of lignan. Manassantin B can be isolated from the ethyl acetate extract of the roots of Saururus chinensis. Manassantin B has cytotoxicities against HT-29 with an IC50 value of 12 μM[1].

Cellular Effect
Cell Line Type Value Description References
P3HR-1 CC50
> 200 μM
Compound: 27
Cytotoxicity against human P3HR1 cells assessed as cell viability after 2 days by trypan blue staining-based light microscopy
Cytotoxicity against human P3HR1 cells assessed as cell viability after 2 days by trypan blue staining-based light microscopy
[PMID: 24359277]
P3HR-1 EC50
1.72 μM
Compound: 27
Antiviral activity against EBV infected in human P3HR1 cells assessed as inhibition of lytic viral DNA replication after 48 hrs by RT-PCR analysis
Antiviral activity against EBV infected in human P3HR1 cells assessed as inhibition of lytic viral DNA replication after 48 hrs by RT-PCR analysis
[PMID: 24359277]
T47D IC50
3 nM
Compound: 1, manassantin B
Inhibition of hypoxia-induced HIF1 activation in human T47D cells after 16 hrs by pTK-HRE3-luciferase reporter gene assay
Inhibition of hypoxia-induced HIF1 activation in human T47D cells after 16 hrs by pTK-HRE3-luciferase reporter gene assay
[PMID: 15165135]
Molecular Weight

716.81

Formula

C41H48O11
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

C[C@H]1[C@@H](C2=CC(OC)=C(C=C2)O[C@H](C)[C@@H](C3=CC(OC)=C(C=C3)OC)O)O[C@H](C4=CC(OC)=C(C=C4)O[C@H](C)[C@@H](C5=CC=C(OCO6)C6=C5)O)[C@@H]1C
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility
In Vitro: 

DMSO : 10 mg/mL (13.95 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.3951 mL 6.9753 mL 13.9507 mL
5 mM 0.2790 mL 1.3951 mL 2.7901 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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In Vivo Dissolution Calculator
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Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.3951 mL 6.9753 mL 13.9507 mL 34.8767 mL
5 mM 0.2790 mL 1.3951 mL 2.7901 mL 6.9753 mL
10 mM 0.1395 mL 0.6975 mL 1.3951 mL 3.4877 mL
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Manassantin B Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Manassantin B88497-88-5(-)-Manassantin BOthersNatural Products,LignanInhibitorinhibitorinhibit

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