Mant-GTPγS 

Mant-GTPγS, a GTP mimetic, is a potent competitive adenylyl cyclase (AC) inhibitor. Mant-GTPγS is a potent YdeH inhibitor^[1][2][3].

672.39

C₁₈H₂₃N₆O₁₄P₃S

136749-24-1

Liquid

Colorless to light yellow

O=C(C1=CC=CC=C1NC)[穄.O=C2C(N=CN3[C@H]4[C@H](O[R])[C@H](O[R])[C@@H](COP(OP(OP(O)(O)=S)(O)=O)(O)=O)O4)=C3N=C(N)N2.[or].[H]

Room temperature in continental US; may vary elsewhere.

Solution, -20°C, 2 years

• [1]. Andreas Gille, et al. 2'(3')-O-(N-methylanthraniloyl)-substituted GTP analogs: a novel class of potent competitive adenylyl cyclase inhibitors. J Biol Chem. 2003 Apr 11;278(15):12672-9.  [Content Brief]

  [2]. Tomoharu Kanie, et al. The CEP19-RABL2 GTPase Complex Binds IFT-B to Initiate Intraflagellar Transport at the Ciliary Base. Dev Cell. 2017 Jul 10;42(1):22-36.e12.  [Content Brief]

  [3]. Christian Spangler, et al. Interaction of the diguanylate cyclase YdeH of Escherichia coli with 2',(3')-substituted purine and pyrimidine nucleotides. J Pharmacol Exp Ther. 2011 Jan;336(1):234-41.  [Content Brief]