MAO-B-IN-21 

MAO-B-IN-21 is an excellent MAO-B inhibitor with antioxidant activity and anti-Aβ aggregation activity. MAO-B-IN-21 also exhibits metal-ion chelating ability, anti-neuroinflammation (NO, TNF-α), neuroprotective activity and BBB permeability. MAO-B-IN-21 significantly improves the memory and cognitive impairment in Aβ1-42 induced Alzheimer's disease mice model^[1].

MAO-B-IN-21 (37.5 μM in methanol) blocks Cu²⁺-induced ROS production, due to metal-chelating property and/or its antioxidant capacity to capture the free radicals from Cu²⁺-Ascorbate redox system^[1].
MAO-B-IN-21 (25 μM; 24 h; 37 ℃) inhibits self-induced Aβ_1-42 aggregation and disaggregate self-induced Aβ1-42 fibrils^[1].
MAO-B-IN-21 (2.5-25 μM; 24 h) inhibits ROS production in LPS-stimulated BV-2 microglia cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

MAO-B-IN-21 (30 mg/kg; ig; single dose) could cross the BBB easily in Balb/C mice^[1].
MAO-B-IN-21 (8 mg/kg and 32 mg/kg; ig; single dose) shortenes the escape latency time (ELT), reduced Aβ_1-42 level, indicating the improvement in learning and memory ability in Aβ-induced AD mice model^[1].

Pharmacokinetic Analysis in Balb/C mice^[1]

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

440.92

C₂₄H₂₅ClN₂O₄

2956426-18-7

CCCCCCCC1OC(C2=CC(N3N=C(CC3=O)C4=CC(Cl)=CC=C4O)=CC=C21)=O

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Cong S, et al. Discovery of novel 5-(2-hydroxyphenyl)-2-phthalide-3(3H)-pyrazolones as balanced multifunctional agents against Alzheimer's disease. Eur J Med Chem. 2023 Mar 15;250:115216.  [Content Brief]