MAT2A-IN-14

Cat. No.: HY-162135: FAQs
Data Sheet Handling Instructions

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MAT2A-IN-14 (compound H3) is a MAT2A inhibitor, and generates reactive oxygen species after sonication to specifically degrade cellular MAT2A via rapid oxidative reactions. Combination of MAT2A-IN-14 and sonication induces 87% MAT2A depletion in human colon cancer cell.

For research use only. We do not sell to patients.

MAT2A-IN-14 Chemical Structure

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Description	MAT2A-IN-14 (compound H3) is a MAT2A inhibitor, and generates reactive oxygen species after sonication to specifically degrade cellular MAT2A via rapid oxidative reactions. Combination of MAT2A-IN-14 and sonication induces 87% MAT2A depletion in human colon cancer cell^[1].
Molecular Weight	506.50
Formula	C₂₇H₂₄F₂N₄O₄
SMILES	O=C1C(C2=CC=C(C3=C2)OCC4N3CCC4)=CC(C=NC(OCC)=N5)=C5N1C6=CC=C(C=C6)OC(F)F
Shipping	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation	Data Sheet (269 KB) Handling Instructions (2659 KB)
References	[1]. He H, et al. Identification of a Sonically Activated Degrader of Methionine Adenosyltransferase 2A by an in Silico Approach Assisted with the Hole-Electron Analysis. J Med Chem. 2024;67(1):543-554. [Content Brief]

MAT2A-IN-14 Related Classifications

Molarity Calculator
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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass		Concentration		Volume		Molecular Weight *
	=		×		×

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MAT2A-IN-14Reactive Oxygen SpeciesMethionine Adenosyltransferase (MAT)S-adenosylmethionine Synthetasereactive oxygen speciescolon cancer cellMAT2AInhibitorinhibitorinhibit

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MAT2A-IN-14

MAT2A-IN-14 Related Antibodies

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