1. Antibody-drug Conjugate/ADC Related
  2. Drug-Linker Conjugates for ADC
  3. MC-betaglucuronide-MMAE-1

MC-betaglucuronide-MMAE-1 is a agent-linker conjugate for ADC with potent antitumor activity by using MMAE (a tubulin polymerization inhibitor), linked via the cleavable ADC linker MC-betaglucuronide.

For research use only. We do not sell to patients.

MC-betaglucuronide-MMAE-1 Chemical Structure

MC-betaglucuronide-MMAE-1 Chemical Structure

CAS No. : 1703778-92-0

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1 mg USD 520 In-stock
5 mg USD 1450 In-stock
10 mg USD 2400 In-stock
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Customer Review

Based on 1 publication(s) in Google Scholar

Top Publications Citing Use of Products
  • Biological Activity

  • Purity & Documentation

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Description

MC-betaglucuronide-MMAE-1 is a agent-linker conjugate for ADC with potent antitumor activity by using MMAE (a tubulin polymerization inhibitor), linked via the cleavable ADC linker MC-betaglucuronide.

IC50 & Target

Auristatin

 

Molecular Weight

1323.53

Formula

C66H98N8O20

CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O[C@H]1[C@H](O)[C@@H](O)[C@H](OC2=C(NC(CCNC(CCCCCN3C(C=CC3=O)=O)=O)=O)C=C(COC(N(C)[C@@H](C(C)C)C(N[C@H](C(N(C)[C@@H]([C@H](CC)C)[C@H](OC)CC(N4[C@H]([C@H](OC)[C@@H](C)C(N[C@H](C)[C@@H](O)C5=CC=CC=C5)=O)CCC4)=O)=O)C(C)C)=O)=O)C=C2)O[C@@H]1C(O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, protect from light

*The compound is unstable in solutions, freshly prepared is recommended.

Solvent & Solubility
In Vitro: 

DMSO : 200 mg/mL (151.11 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.7556 mL 3.7778 mL 7.5556 mL
5 mM 0.1511 mL 0.7556 mL 1.5111 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. The compound is unstable in solutions, freshly prepared is recommended.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
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Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

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Volume (start)

V1

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Concentration (final)

C2

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Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

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g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. The compound is unstable in solutions, freshly prepared is recommended.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 0.7556 mL 3.7778 mL 7.5556 mL 18.8889 mL
5 mM 0.1511 mL 0.7556 mL 1.5111 mL 3.7778 mL
10 mM 0.0756 mL 0.3778 mL 0.7556 mL 1.8889 mL
15 mM 0.0504 mL 0.2519 mL 0.5037 mL 1.2593 mL
20 mM 0.0378 mL 0.1889 mL 0.3778 mL 0.9444 mL
25 mM 0.0302 mL 0.1511 mL 0.3022 mL 0.7556 mL
30 mM 0.0252 mL 0.1259 mL 0.2519 mL 0.6296 mL
40 mM 0.0189 mL 0.0944 mL 0.1889 mL 0.4722 mL
50 mM 0.0151 mL 0.0756 mL 0.1511 mL 0.3778 mL
60 mM 0.0126 mL 0.0630 mL 0.1259 mL 0.3148 mL
80 mM 0.0094 mL 0.0472 mL 0.0944 mL 0.2361 mL
100 mM 0.0076 mL 0.0378 mL 0.0756 mL 0.1889 mL
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
MC-betaglucuronide-MMAE-1
Cat. No.:
HY-136317
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