MC-betaglucuronide-MMAE-1

Cat. No.: HY-136317 Purity: 99.72%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

MC-betaglucuronide-MMAE-1 is a agent-linker conjugate for ADC with potent antitumor activity by using MMAE (a tubulin polymerization inhibitor), linked via the cleavable ADC linker MC-betaglucuronide.

For research use only. We do not sell to patients.

MC-betaglucuronide-MMAE-1 Chemical Structure

CAS No. : 1703778-92-0

Size	Price	Stock	Quantity
1 mg	USD 520	In-stock	Estimated Time of Arrival: December 31
5 mg	USD 1450	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 2400	In-stock	Estimated Time of Arrival: December 31
50 mg		Get quote
100 mg		Get quote

or Bulk Inquiry

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 1 publication(s) in Google Scholar

Featured Recommendations

•Related Small Molecules:

•Related Proteins:

View All Drug-Linker Conjugates for ADC Isoform Specific Products:

View All Isoforms

Auristatin Camptothecins Daunorubicins/Doxorubicins Duocarmycins Maytansinoids Pyrrolobenzodiazepines Traditional Cytotoxic Agents

Biological Activity
Purity & Documentation
References
Customer Review

Description

IC₅₀ & Target

Auristatin

Molecular Weight

1323.53

Formula

C₆₆H₉₈N₈O₂₀

CAS No.

1703778-92-0

Appearance

Solid

Color

White to off-white

SMILES

O[C@H]1[C@H](O)[C@@H](O)[C@H](OC2=C(NC(CCNC(CCCCCN3C(C=CC3=O)=O)=O)=O)C=C(COC(N(C)[C@@H](C(C)C)C(N[C@H](C(N(C)[C@@H]([C@H](CC)C)[C@H](OC)CC(N4[C@H]([C@H](OC)[C@@H](C)C(N[C@H](C)[C@@H](O)C5=CC=CC=C5)=O)CCC4)=O)=O)C(C)C)=O)=O)C=C2)O[C@@H]1C(O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, protect from light

*The compound is unstable in solutions, freshly prepared is recommended.

Solvent & Solubility

In Vitro:

DMSO : 200 mg/mL (151.11 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	0.7556 mL	3.7778 mL	7.5556 mL
5 mM	0.1511 mL	0.7556 mL	1.5111 mL
10 mM	0.0756 mL	0.3778 mL	0.7556 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. The compound is unstable in solutions, freshly prepared is recommended.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.72%

Select Batch:

Data Sheet (269 KB) SDS (252 KB)

COA (250 KB) HNMR (436 KB) RP-HPLC (264 KB) LCMS (98 KB)

Handling Instructions (2659 KB)

References

[1]. Okeley, et al. Intracellular Activation of SGN-35, a Potent Anti-CD30 Antibody-Drug Conjugate. Clinical Cancer Research (2010), 16(3), 888-897. [Content Brief]

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. The compound is unstable in solutions, freshly prepared is recommended.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	0.7556 mL	3.7778 mL	7.5556 mL	18.8889 mL
	5 mM	0.1511 mL	0.7556 mL	1.5111 mL	3.7778 mL
	10 mM	0.0756 mL	0.3778 mL	0.7556 mL	1.8889 mL
	15 mM	0.0504 mL	0.2519 mL	0.5037 mL	1.2593 mL
	20 mM	0.0378 mL	0.1889 mL	0.3778 mL	0.9444 mL
	25 mM	0.0302 mL	0.1511 mL	0.3022 mL	0.7556 mL
	30 mM	0.0252 mL	0.1259 mL	0.2519 mL	0.6296 mL
	40 mM	0.0189 mL	0.0944 mL	0.1889 mL	0.4722 mL
	50 mM	0.0151 mL	0.0756 mL	0.1511 mL	0.3778 mL
	60 mM	0.0126 mL	0.0630 mL	0.1259 mL	0.3148 mL
	80 mM	0.0094 mL	0.0472 mL	0.0944 mL	0.2361 mL
	100 mM	0.0076 mL	0.0378 mL	0.0756 mL	0.1889 mL