2. Antibody-drug Conjugate/ADC Related PROTAC
  3. PROTAC-Linker Conjugates for PAC
  4. MC-(β-Ala)-PABC-(β-D-GlcUA)-amide-PEG1-CH2-CC-885

MC-(β-Ala)-PABC-(β-D-GlcUA)-amide-PEG1-CH2-CC-885 

Cat. No.: HY-160497 Purity: 99.63%
COA Handling Instructions

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MC-(β-Ala)-PABC-(β-D-GlcUA)-amide-PEG1-CH2-CC-885 (Comp Ie) is a neodegrader conjugate, can be used in the synthesis of antibody neoDegrader conjugate (AnDC).

For research use only. We do not sell to patients.

MC-(β-Ala)-PABC-(β-D-GlcUA)-amide-PEG1-CH2-CC-885 Chemical Structure

MC-(β-Ala)-PABC-(β-D-GlcUA)-amide-PEG1-CH2-CC-885 Chemical Structure

CAS No. : 2722697-86-9

Size Price Stock Quantity
1 mg USD 900 In-stock
5 mg USD 2470 In-stock
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50 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

MC-(β-Ala)-PABC-(β-D-GlcUA)-amide-PEG1-CH2-CC-885 Related Antibodies

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  • Purity & Documentation

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Description

MC-(β-Ala)-PABC-(β-D-GlcUA)-amide-PEG1-CH2-CC-885 (Comp Ie) is a neodegrader conjugate, can be used in the synthesis of antibody neoDegrader conjugate (AnDC)[1].

Molecular Weight

1133.55

Formula

C53H61ClN8O18
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C1C2=CC=C(CNC(NC3=CC(Cl)=C(C=C3)CCOCCN(C)C(OCC4=CC(NC(CCNC(CCCCCN5C(C=CC5=O)=O)=O)=O)=C(C=C4)O[C@@H]6O[C@@H]([C@H]([C@@H]([C@H]6O)O)O)C(O)=O)=O)=O)C=C2CN1C7C(NC(CC7)=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (88.22 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.8822 mL 4.4109 mL 8.8218 mL
5 mM 0.1764 mL 0.8822 mL 1.7644 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

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g

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(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 0.8822 mL 4.4109 mL 8.8218 mL 22.0546 mL
5 mM 0.1764 mL 0.8822 mL 1.7644 mL 4.4109 mL
10 mM 0.0882 mL 0.4411 mL 0.8822 mL 2.2055 mL
15 mM 0.0588 mL 0.2941 mL 0.5881 mL 1.4703 mL
20 mM 0.0441 mL 0.2205 mL 0.4411 mL 1.1027 mL
25 mM 0.0353 mL 0.1764 mL 0.3529 mL 0.8822 mL
30 mM 0.0294 mL 0.1470 mL 0.2941 mL 0.7352 mL
40 mM 0.0221 mL 0.1103 mL 0.2205 mL 0.5514 mL
50 mM 0.0176 mL 0.0882 mL 0.1764 mL 0.4411 mL
60 mM 0.0147 mL 0.0735 mL 0.1470 mL 0.3676 mL
80 mM 0.0110 mL 0.0551 mL 0.1103 mL 0.2757 mL
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MC-(β-Ala)-PABC-(β-D-GlcUA)-amide-PEG1-CH2-CC-885 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MC-(β-Ala)-PABC-(β-D-GlcUA)-amide-PEG1-CH2-CC-8852722697-86-9PROTAC-Linker Conjugates for PACPROTAC-Linker for PROTAC-antibody ConjugatesInhibitorinhibitorinhibit

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