2. Metabolic Enzyme/Protease Neuronal Signaling NF-κB Immunology/Inflammation
  3. NADPH Oxidase Monoamine Oxidase Reactive Oxygen Species NO Synthase Interleukin Related
  4. MC4762

MC4762 is an inhibitor of NOX2 and MAOB, with IC50 values of 0.155 μM and 0.182 μM, respectively. MC4762 has anti-inflammatory activity, can inhibit the production of ROS, and downregulate the expression of pro-inflammatory cytokines iNOS, IL-1β, and IL-6.

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MC4762 Chemical Structure

MC4762 Chemical Structure

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MC4762 Related Antibodies

Top Publications Citing Use of Products

View All NADPH Oxidase Isoform Specific Products:

View All Isoforms
NOX1 NOX2 NOX4

View All Monoamine Oxidase Isoform Specific Products:

View All Isoforms
MAO-A MAO-B

View All NO Synthase Isoform Specific Products:

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nNOS iNOS eNOS

View All Interleukin Related Isoform Specific Products:

View All Isoforms
IL-1 IL-2 IL-3 IL-4 IL-5 IL-6 IL-8 IL-10 IL-12 IL-13 IL-15 IL-17 IL-23 IL-7 IL-33 IL-22

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Description

MC4762 is an inhibitor of NOX2 and MAOB, with IC50 values of 0.155 μM and 0.182 μM, respectively. MC4762 has anti-inflammatory activity, can inhibit the production of ROS, and downregulate the expression of pro-inflammatory cytokines iNOS, IL-1β, and IL-6[1].

IC50 & Target[1]

MAO-B

0.182 μM (IC50)

NOX2

0.155 μM (IC50)

Molecular Weight

441.51

Formula

C23H19N7OS
SMILES

C#CCN(CC1=CC=C(CN2N=NC3=C(SC4=NC5=CC=CC=C5O4)N=CN=C32)C=C1)C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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MC4762 Related Classifications

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The dilution calculator equation

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This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MC4762MC 4762MC-4762NADPH OxidaseMonoamine OxidaseReactive Oxygen SpeciesNO SynthaseInterleukin RelatedNOXMAONitric oxide synthasesNOSILHEK293BV2Inhibitorinhibitorinhibit

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