2. Academic Validation
  3. Paclitaxel analogues from Taxus x media cv. Hicksii

Paclitaxel analogues from Taxus x media cv. Hicksii

  • J Nat Prod. 1999 Feb;62(2):219-23. doi: 10.1021/np9802264.
B Gabetta 1,  N Fuzzati,  P Orsini,  F Peterlongo,  G Appendino,  D G Vander Velde
Affiliations

Affiliation

  • 1 Indena S.p.A, via Don Minzoni 6, 20090 Settala (MI), Dipartimento di Scienza e Tecnologia del Farmaco, via Giuria 9, 10125 Torino, Italy. speclab@tin.it
PMID: 10075745 DOI: 10.1021/np9802264
Abstract

The roots of T. x media Rehd. cv. Hicksii gave three novel analogues of paclitaxel modified at the N-acyl residue (N-debenzoyl-N-alpha-methylbutyryl paclitaxel and N-debenzoyl-N-cinnamoyl paclitaxel, 1b and 1c, respectively) or at the ester group at C-2 (2-debenzoyl-2-tigloyl paclitaxel, 1d). Compounds 1b and 1d showed reduced cytotoxicity and tubulin binding compared to paclitaxel, while 1c retained substantial activity in these assays.

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