2. Academic Validation
  3. Pregnane glycoside multidrug-resistance modulators from Cynanchum wilfordii

Pregnane glycoside multidrug-resistance modulators from Cynanchum wilfordii

  • J Nat Prod. 1999 Apr;62(4):640-3. doi: 10.1021/np980479x.
B Y Hwang 1,  S E Kim,  Y H Kim,  H S Kim,  Y S Hong,  J S Ro,  K S Lee,  J J Lee
Affiliations

Affiliation

  • 1 Natural Product Biosynthesis Research Unit, Korea Research Institute of Bioscience, and Biotechnology, P.O. Box 115, Yusong, Taejon 305-600, Korea.
PMID: 10217732 DOI: 10.1021/np980479x
Abstract

The methanol-soluble extracts of the roots of Cynanchum wilfordii showed a significant multidrug-resistance-reversing activity, and four known pregnane glycosides were isolated by bioassay-directed fractionation and separation. Their structures were identified as gagaminin 3-O-beta-D-cymaropyranosyl-(1-->4)-beta-D-oleandropyranosyl- (1-->4)-b eta-D-cymaropyranosyl-(1-->4)-beta-D-cymaropyranoside (1), wilfoside K1N (2), wilfoside C1N (3), and cynauricuoside A (4). In particular, compound 1, at a concentration level of 1 microM, was found to completely reverse the multidrug-resistance of KB-V1 and MCF7/ADR cells to adriamycin, vinblastine, and colchicine.

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