1. Academic Validation
  2. Cell activation and apoptosis by bacterial lipoproteins through toll-like receptor-2

Cell activation and apoptosis by bacterial lipoproteins through toll-like receptor-2

  • Science. 1999 Jul 30;285(5428):736-9. doi: 10.1126/science.285.5428.736.
A O Aliprantis 1 R B Yang M R Mark S Suggett B Devaux J D Radolf G R Klimpel P Godowski A Zychlinsky
Affiliations

Affiliation

  • 1 Skirball Institute and Department of Microbiology, New York University School of Medicine, 540 First Avenue, New York, NY 10016, USA.
Abstract

Apoptosis is implicated in the generation and resolution of inflammation in response to Bacterial pathogens. All Bacterial pathogens produce lipoproteins (BLPs), which trigger the innate immune response. BLPs were found to induce Apoptosis in THP-1 monocytic cells through human Toll-like receptor-2 (hTLR2). BLPs also initiated Apoptosis in an epithelial cell line transfected with hTLR2. In addition, BLPs stimulated nuclear factor-kappaB, a transcriptional activator of multiple host defense genes, and activated the respiratory burst through hTLR2. Thus, hTLR2 is a molecular link between microbial products, Apoptosis, and host defense mechanisms.

Figures