2. Academic Validation
  3. Semisynthesis and cytotoxicity of styryl-lactone derivatives

Semisynthesis and cytotoxicity of styryl-lactone derivatives

  • J Nat Prod. 1999 Aug;62(8):1106-9. doi: 10.1021/np990089q.
A Bermejo 1,  S Léonce,  N Cabedo,  I Andreu,  D H Caignard,  G Atassi,  D Cortes
Affiliations

Affiliation

  • 1 Departamento de Farmacología, Farmacognosia y Farmacodinamia, Facultad de Farmacia, Universidad de Valencia, 46100 Burjassot, Valencia, Spain.
PMID: 10479313 DOI: 10.1021/np990089q
Abstract

The cytotoxicity and the cell-cycle action of altholactone (1), goniofufurone (2), and eight altholactone derivatives (5-12), were determined in vitro on L-1210 cells. Semisyntheses and structure-activity relationships of these compounds are described. The results of this study suggest that the cytotoxicity of altholactone (1), 11-nitro-altholactone (8), and 7-chloro-6,7-dihydroaltholactone (10) is due to the accumulation of the cells in the G2 + M phase of the cell cycle.

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