2. Academic Validation
  3. Biologically active carbazole alkaloids from Murraya koenigii

Biologically active carbazole alkaloids from Murraya koenigii

  • J Agric Food Chem. 1999 Feb;47(2):444-7. doi: 10.1021/jf9805808.
R S Ramsewak 1,  M G Nair,  G M Strasburg,  D L DeWitt,  J L Nitiss
Affiliations

Affiliation

  • 1 Department of Horticulture and National Food Safety and Toxicology Center, Michigan State University, East Lansing 48824, USA.
PMID: 10563914 DOI: 10.1021/jf9805808
Abstract

The bioassay guided fractionation of the acetone extract of the fresh leaves of Murraya koenigii resulted in the isolation of three bioactive Carbazole Alkaloids, mahanimbine (1), murrayanol (2), and mahanine (3), as confirmed from their (1)H and (13)C NMR spectral data. Compound 2 showed an IC(50) of 109 microg/mL against hPGHS-1 and an IC(50) of 218 microg/mL against hPGHS-2 in antiinflammatory assays, while compound 1 displayed antioxidant activity at 33.1 microg/mL. All three compounds were mosquitocidal and antimicrobial and exhibited Topoisomerase I and II inhibition activities.

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