2. Academic Validation
  3. A cytotoxic 5alpha,8alpha-epidioxysterol from a soft coral Sinularia species

A cytotoxic 5alpha,8alpha-epidioxysterol from a soft coral Sinularia species

  • J Nat Prod. 2000 Jan;63(1):149-51. doi: 10.1021/np9903954.
J H Sheu 1,  K C Chang,  C Y Duh
Affiliations

Affiliation

  • 1 Department of Marine Resources, National Sun Yat-Sen University, Kaohsiung, Taiwan 804, Republic of China. sheu@mail.nsysu.edu.tw
PMID: 10650100 DOI: 10.1021/np9903954
Abstract

A new sterol, (22R,23R,24R)-5alpha,8alpha-epidioxy-22, 23-methylene-24-methylcholest-6-en-3beta-ol (1), as well as two known sterols, numersterol A (2) and pregnenolone (3), have been isolated from a soft coral Sinularia sp. The structure of metabolite 1 was determined by spectral analysis. Cytotoxicity of sterols 1-3 toward various Cancer cell lines is also reported.

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