2. Academic Validation
  3. Elucidation of protein-protein interactions using chemical cross-linking or label transfer techniques

Elucidation of protein-protein interactions using chemical cross-linking or label transfer techniques

  • Curr Opin Chem Biol. 2000 Feb;4(1):28-33. doi: 10.1016/s1367-5931(99)00047-2.
D A Fancy 1
Affiliations

Affiliation

  • 1 Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, TX 75235-9050, USA. fancy@chop.swmed.edu.
PMID: 10679368 DOI: 10.1016/s1367-5931(99)00047-2
Abstract

Understanding the architectures of multiprotein complexes is a central problem in biology. Of the many chemical methods available, label transfer and cross-linking are becoming more popular. Recently, label transfer has been applied to very large protein complexes with great success, and new oxidative methods for protein cross-linking have been developed that are fast and highly efficient. Advances in these techniques should increase the understanding of biological structures and mechanisms.

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