2. Academic Validation
  3. Inhibition of cyclooxygenase-2 expression by diarylheptanoids from the bark of Alnus hirsuta var. sibirica

Inhibition of cyclooxygenase-2 expression by diarylheptanoids from the bark of Alnus hirsuta var. sibirica

  • Biol Pharm Bull. 2000 Apr;23(4):517-8. doi: 10.1248/bpb.23.517.
M W Lee 1,  J H Kim,  D W Jeong,  K H Ahn,  S H Toh,  Y J Surh
Affiliations

Affiliation

  • 1 College of Pharmacy, Chung-Ang University, Seoul, Korea.
PMID: 10784440 DOI: 10.1248/bpb.23.517
Abstract

Two known diarylheptanoids, oregonin (1), (5S)-1,7-bis-(3,4-dihydroxyphenyl)-heptane-3-one-5-O-beta-D-xylopyranosi de and hirsutanonol (2), (5S)-1,7-bis-(3,4-dihydroxyphenyl)-5-hydroxyheptane-3-one isolated from the bark of Alnus hirsuta var. sibirica, showed significant inhibitory effects on 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced cyclooxygenase-2 (COX-2) expression in immortalized human breast epithelial MCF10A cells.

Figures
Products