2. Academic Validation
  3. Apelin peptides block the entry of human immunodeficiency virus (HIV)

Apelin peptides block the entry of human immunodeficiency virus (HIV)

  • FEBS Lett. 2000 May 4;473(1):15-8. doi: 10.1016/s0014-5793(00)01487-3.
M X Zou 1,  H Y Liu,  Y Haraguchi,  Y Soda,  K Tatemoto,  H Hoshino
Affiliations

Affiliation

  • 1 Department of Molecular Physiology, Institute for Molecular and Cellular Regulation, Gunma University, Maebashi, Japan.
PMID: 10802050 DOI: 10.1016/s0014-5793(00)01487-3
Abstract

The orphan G protein-coupled receptor APJ has been shown to be a coreceptor for human and simian immunodeficiency virus (HIV and SIV) strains. We have determined that some HIV and SIV strains use APJ as a coreceptor to infect the brain-derived NP-2/CD4 cells. Because apelin is an endogenous ligand for the APJ receptor, we examined the inhibitory effects of apelin Peptides on HIV Infection, and found that the apelin Peptides inhibit the entry of some HIV-1 and HIV-2 into the NP-2/CD4 cells expressing APJ. The inhibitory efficiency has been found to be in the order of apelin-36>apelin-17>apelin-13>apelin-12.

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