PDGF-C is a new protease-activated ligand for the PDGF alpha-receptor

Nat Cell Biol. 2000 May;2(5):302-9. doi: 10.1038/35010579.

X Li ¹, A Pontén, K Aase, L Karlsson, A Abramsson, M Uutela, G Bäckström, M Hellström, H Boström, H Li, P Soriano, C Betsholtz, C H Heldin, K Alitalo, A Ostman, U Eriksson

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Affiliation

1 Ludwig Institute for Cancer Research, Stockholm, Sweden.

PMID: 10806482 DOI: 10.1038/35010579

Abstract

Platelet-derived growth factors (PDGFs) are important in many types of mesenchymal cell. Here we identify a new PDGF, PDGF-C, which binds to and activates the PDGF alpha-receptor. PDGF-C is activated by proteolysis and induces proliferation of fibroblasts when overexpressed in transgenic mice. In situ hybridization analysis in the murine embryonic kidney shows preferential expression of PDGF-C messenger RNA in the metanephric mesenchyme during epithelial conversion. Analysis of kidneys lacking the PDGF alpha-receptor shows selective loss of mesenchymal cells adjacent to sites of expression of PDGF-C mRNA; this is not found in kidneys from Animals lacking PDGF-A or both PDGF-A and PDGF-B, indicating that PDGF-C may have a unique function.

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