2. Academic Validation
  3. Substituted 5,7-diphenyl-pyrrolo[2,3d]pyrimidines: potent inhibitors of the tyrosine kinase c-Src

Substituted 5,7-diphenyl-pyrrolo[2,3d]pyrimidines: potent inhibitors of the tyrosine kinase c-Src

  • Bioorg Med Chem Lett. 2000 May 1;10(9):945-9. doi: 10.1016/s0960-894x(00)00131-1.
M Missbach 1,  E Altmann,  L Widler,  M Susa,  E Buchdunger,  H Mett,  T Meyer,  J Green
Affiliations

Affiliation

  • 1 Novartis Pharma AG, Therapeutic Areas Arthritis & Bone Metabolism, Basel, Switzerland. martin.missbach@pharma.novartis.com
PMID: 10853665 DOI: 10.1016/s0960-894x(00)00131-1
Abstract

5,7-Diphenyl-pyrrolo[2,3d]pyrimidines represent a new class of highly potent inhibitors of the tyrosine kinase c-Src (IC50 < 50 nM) with specificity against a panel of different tyrosine kinases. The substitution pattern on the two phenyl rings determines potency and specificity and provides a means to modulate cellular activity.

Figures
Products
  • Cat. No.
    Product Name
    Description
    Target
    Research Area
  • HY-171218
    c-Src Inhibtior
    Src