2. Academic Validation
  3. Hepatitis C viral IRES inhibition by phenazine and phenazine-like molecules

Hepatitis C viral IRES inhibition by phenazine and phenazine-like molecules

  • Bioorg Med Chem Lett. 2000 Jun 5;10(11):1151-4. doi: 10.1016/s0960-894x(00)00217-1.
W Wang 1,  P Préville,  N Morin,  S Mounir,  W Cai,  M A Siddiqui
Affiliations

Affiliation

  • 1 BioChem Pharma Inc., Laval, Québec, Canada. wangwu@biochempharma.com
PMID: 10866369 DOI: 10.1016/s0960-894x(00)00217-1
Abstract

An in vitro assay based on the expression of Fluci reporter gene under the translational control of HCV IRES was used to evaluate and screen compound libraries. A structure-activity relationship study on a phenazine hit was conducted. Our data suggest that an intact phenazine or phenazine-like core with two distal polar substitutions is crucial for potency.

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