2. Academic Validation
  3. Bicyclic nucleoside inhibitors of Varicella-Zoster Virus (VZV): the effect of a terminal halogen substitution in the side-chain

Bicyclic nucleoside inhibitors of Varicella-Zoster Virus (VZV): the effect of a terminal halogen substitution in the side-chain

  • Bioorg Med Chem Lett. 2000 Jun 5;10(11):1215-7. doi: 10.1016/s0960-894x(00)00193-1.
A Brancale 1,  C McGuigan,  G Andrei,  R Snoeck,  E De Clercq,  J Balzarini
Affiliations

Affiliation

  • 1 Welsh School of Pharmacy, Cardiff University, UK.
PMID: 10866384 DOI: 10.1016/s0960-894x(00)00193-1
Abstract

Preliminary SAR studies on the side chain of a new class of Antiviral nucleosides have shown that terminal substitution in the side-chain, with a halogen atom, lead to potent and highly specific anti-VZV agents.

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