2. Academic Validation
  3. A focused compound library of novel N-(7-indolyl)benzenesulfonamides for the discovery of potent cell cycle inhibitors

A focused compound library of novel N-(7-indolyl)benzenesulfonamides for the discovery of potent cell cycle inhibitors

  • Bioorg Med Chem Lett. 2000 Jun 5;10(11):1223-6. doi: 10.1016/s0960-894x(00)00219-5.
T Owa 1,  T Okauchi,  K Yoshimatsu,  N H Sugi,  Y Ozawa,  T Nagasu,  N Koyanagi,  T Okabe,  K Kitoh,  H Yoshino
Affiliations

Affiliation

  • 1 Tsukuba Research Laboratories, Eisai Co., Ltd., Ibaraki, Japan. t-owa@hhc.eisai.co.jp
PMID: 10866386 DOI: 10.1016/s0960-894x(00)00219-5
Abstract

A series of compounds containing an N-(7-indolyl)benzenesulfonamide pharmacophore was synthesized and evaluated as a potential antitumor agent. Cell cycle analysis with P388 murine leukemia cells revealed that there were two different classes of potent cell cycle inhibitors; one disrupted mitosis and the Other caused G1 accumulation. Herein described is the SAR summary of the substituent patterns on this pharmacophore template.

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