2. Academic Validation
  3. Design and evaluation of dihydroisoquinolines as potent and orally bioavailable human cytomegalovirus inhibitors

Design and evaluation of dihydroisoquinolines as potent and orally bioavailable human cytomegalovirus inhibitors

  • Bioorg Med Chem Lett. 2000 Jul 3;10(13):1477-80. doi: 10.1016/s0960-894x(00)00265-1.
L Chan 1,  T Stefanac,  N Turcotte,  Z Hu,  Y Chen,  J Bédard,  S May,  H Jin
Affiliations

Affiliation

  • 1 BioChem Pharma Inc., Laval, Québec, Canada. chanl@biochempharma.com
PMID: 10888336 DOI: 10.1016/s0960-894x(00)00265-1
Abstract

Following the identification of first pass metabolism issues with our recently described anti-HCMV compounds, the naphthyridines and isoquinolines, we have designed a class of novel metabolically stable and orally bioavailable anti-HCMV agents, the dihydroisoquinolines.

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