2. Academic Validation
  3. Synthesis and in vitro evaluation of human FP-receptor selective prostaglandin analogues

Synthesis and in vitro evaluation of human FP-receptor selective prostaglandin analogues

  • Bioorg Med Chem Lett. 2000 Jul 17;10(14):1519-22. doi: 10.1016/s0960-894x(00)00273-0.
M A deLong 1,  J Amburgey,  C Taylor,  J A Wos,  D L Soper,  Y Wang,  R Hicks
Affiliations

Affiliation

  • 1 Procter & Gamble Pharmaceuticals, Mason, OH 45040, USA. delong.ma@pg.com
PMID: 10915040 DOI: 10.1016/s0960-894x(00)00273-0
Abstract

The in vitro evaluation of a series of saturated prostaglandins revealed that compounds with omega chain aromatic rings retain nanomolar potency for the human prostaglandin F receptor (hFP receptor), exemplified by compound 8. In contrast, the double bonds are required for activity in the series with an acyclic omega chain as in PGF2alpha.

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