2. Academic Validation
  3. Cytotoxic constituents of Polyalthia longifolia var. pendula

Cytotoxic constituents of Polyalthia longifolia var. pendula

  • J Nat Prod. 2000 Nov;63(11):1475-8. doi: 10.1021/np000176e.
C Y Chen 1,  F R Chang,  Y C Shih,  T J Hsieh,  Y C Chia,  H Y Tseng,  H C Chen,  S J Chen,  M C Hsu,  Y C Wu
Affiliations

Affiliation

  • 1 Graduate Institute of Natural Products, Kaohsiung Medical University, Kaohsiung 807, Taiwan.
PMID: 11087586 DOI: 10.1021/np000176e
Abstract

A new halimane diterpene, 3beta,5beta, 16alpha-trihydroxyhalima-13(14)-en-15,16-olide (1), and a new oxoprotoberberine alkaloid, (-)-8-oxopolyalthiaine (2), along with 20 known compounds, were isolated from a methanolic extract of Polyalthia longifolia var. pendula. The structures of compounds 1 and 2 were established by spectroscopic analysis. Several of these compounds were evaluated for cytotoxicity toward a small panel of human cell lines.

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