2. Academic Validation
  3. Orientia tsutsugamushi infection: overview and immune responses

Orientia tsutsugamushi infection: overview and immune responses

  • Microbes Infect. 2001 Jan;3(1):11-21. doi: 10.1016/s1286-4579(00)01352-6.
S Y Seong 1,  M S Choi,  I S Kim
Affiliations

Affiliation

  • 1 Department of Microbiology and Immunology, Seoul National University College of Medicine and Institute of Endemic Disease, Seoul National University Medical Research Center, 28 Yongon-dong, Chongno-gu, 110-799, Seoul, South Korea.
PMID: 11226850 DOI: 10.1016/s1286-4579(00)01352-6
Abstract

Orientia tsutsugamushi, an obligate intracellular bacterium, was isolated for the first time in 1930. Infections by virulent strains are characterized by fever, rash, eschar, pneumonia, myocarditis, and disseminated intravascular coagulation. Here we review the general aspects of O. tsutsugamushi and immune responses in terms of inflammation, protective immune mechanisms, and immunogenic antigens.

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