2. Academic Validation
  3. A series of quinoline analogues as potent inhibitors of C. albicans prolyl tRNA synthetase

A series of quinoline analogues as potent inhibitors of C. albicans prolyl tRNA synthetase

  • Bioorg Med Chem Lett. 2001 Feb 26;11(4):541-4. doi: 10.1016/s0960-894x(00)00697-1.
X Y Yu 1,  J M Hill,  G Yu,  Y Yang,  A F Kluge,  D Keith,  J Finn,  P Gallant,  J Silverman,  A Lim
Affiliations

Affiliation

  • 1 Department of Medicinal Chemistry, Cubist Pharmaceuticals, Inc., Cambridge, MA 02139, USA. xiang@cubist.com
PMID: 11229766 DOI: 10.1016/s0960-894x(00)00697-1
Abstract

A series of quinoline inhibitors of C. albicans prolyl tRNA synthetase was identified. The most potent analogue, 2-(4-bromo-phenyl)-6-chloro-8-methyl-4-quinolinecarboxylic acid, showed IC50 = 5 nM (CA. ProRS) with high selectivity over the human Enzyme.

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