2. Academic Validation
  3. Monoamine oxidase B inhibitors from the fruits of Opuntia ficus-indica var. saboten

Monoamine oxidase B inhibitors from the fruits of Opuntia ficus-indica var. saboten

  • Arch Pharm Res. 2001 Feb;24(1):51-4. doi: 10.1007/BF02976493.
Y N Han 1,  Y Choo,  Y C Lee,  Y I Moon,  S D Kim,  J W Choi
Affiliations

Affiliation

  • 1 Natural Products Research Institute, Seoul National University, Korea. snake@snu.ac.kr
PMID: 11235812 DOI: 10.1007/BF02976493
Abstract

Three varieties of methyl citrate and 1-methyl malate were isolated from the fruits of Opuntia ficus-indica var. saboten Makino through in vitro bioassay-guided isolation for the inhibition on Monoamine Oxidase(MAO). The IC50 values for MAO-B of 1-monomethyl citrate, 1,3-dimethyl citrate, trimethyl citrate and 1-methyl malate were 0.19, 0.23, 0.61 and 0.25 mM, respectively. However, on MAO-A, their inhibitions showed only marginal activity.

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