2. Academic Validation
  3. Cysteinyl peptide inhibitors of Bacillus cereus zinc beta-lactamase

Cysteinyl peptide inhibitors of Bacillus cereus zinc beta-lactamase

  • Bioorg Med Chem. 2001 Feb;9(2):503-10. doi: 10.1016/s0968-0896(00)00257-1.
S Bounaga 1,  M Galleni,  A P Laws,  M I Page
Affiliations

Affiliation

  • 1 Department of Chemical and Biological Sciences, University of Huddersfield, Queensgate, UK.
PMID: 11249142 DOI: 10.1016/s0968-0896(00)00257-1
Abstract

Several cysteinyl Peptides have been synthesised and shown to be reversible competitive inhibitors of the Bacillus cereus metallo-beta-lactamase. The pH dependence of pKi indicates that the thiol anion displaces hydroxide ion from the active site zinc(II). D,D-Peptides bind to the Enzyme better than other diastereoisomers, which is compatible with the predicted stereochemistry of the active site.

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