2. Academic Validation
  3. Synthesis and in vitro cytotoxicity of novel long chain busulphan analogues

Synthesis and in vitro cytotoxicity of novel long chain busulphan analogues

  • Bioorg Med Chem Lett. 2001 Mar 26;11(6):861-3. doi: 10.1016/s0960-894x(01)00084-1.
G Kokotos 1,  V Constantinou-Kokotou,  J M Padrón,  G J Peters
Affiliations

Affiliation

  • 1 Department of Chemistry, University of Athens, Greece. gkokotos@cc.uoa.gr
PMID: 11277538 DOI: 10.1016/s0960-894x(01)00084-1
Abstract

Two novel long chain alkanediol dimethanesulphonates, analogues of busulphan, were synthesized. Their in vitro cytotoxicity was evaluated against six solid tumor cell lines (A2780, H322, LL, WiDr, C26-10 and UMSCC-22B). 2-Tetradecylbutane-1,4-diol dimethanesulphonate was proved to be the most active compound exhibiting IC50 values between 20.82 and 26.36 microM.

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