2. Academic Validation
  3. A new macrocyclic trichothecene, 12,13-deoxyroridin E, produced by the marine-derived fungus Myrothecium roridum collected in Palau

A new macrocyclic trichothecene, 12,13-deoxyroridin E, produced by the marine-derived fungus Myrothecium roridum collected in Palau

  • J Nat Prod. 2001 Mar;64(3):396-8. doi: 10.1021/np000443g.
M Namikoshi 1,  K Akano,  S Meguro,  I Kasuga,  Y Mine,  T Takahashi,  H Kobayashi
Affiliations

Affiliation

  • 1 Department of Ocean Sciences and Training Vessel Umitaka-maru, Tokyo University of Fisheries, Minato-ku, Tokyo 108-8477, Japan. namikosh@tokyo-u.fish.ac.jp
PMID: 11277768 DOI: 10.1021/np000443g
Abstract

A new macrocyclic trichothecene, 12,13-deoxyroridin E (1), and three known compounds, roridin E (2), verrucarin A (3), and verrucarin J (4), were obtained as cytotoxic components from the marine-derived fungus Myrothecium roridum, isolated in Palau. 12,13-Deoxyroridin E is the second example of a macrocyclic trichothecene possessing a double bond at C-12-C-13 and was about 80-fold less cytotoxic than roridin E, the epoxide variant.

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