2. Academic Validation
  3. The tripartite motif family identifies cell compartments

The tripartite motif family identifies cell compartments

  • EMBO J. 2001 May 1;20(9):2140-51. doi: 10.1093/emboj/20.9.2140.
A Reymond 1,  G Meroni,  A Fantozzi,  G Merla,  S Cairo,  L Luzi,  D Riganelli,  E Zanaria,  S Messali,  S Cainarca,  A Guffanti,  S Minucci,  P G Pelicci,  A Ballabio
Affiliations

Affiliation

  • 1 Telethon Institute of Genetics and Medicine (TIGEM), San Raffaele Biomedical Science Park, Milan, Italy.
PMID: 11331580 DOI: 10.1093/emboj/20.9.2140
Abstract

A functional genomic approach, based on systematic data gathering, was used to characterize a family of proteins containing a tripartite motif (TRIM). A total of 37 TRIM genes/proteins were studied, 21 of which were novel. The results demonstrate that TRIM proteins share a common function: by means of homo-multimerization they identify specific cell compartments.

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