1. Academic Validation
  2. Cytotoxic principles from Ventilago leiocarpa

Cytotoxic principles from Ventilago leiocarpa

  • J Nat Prod. 2001 May;64(5):674-6. doi: 10.1021/np000569d.
L C Lin 1 C J Chou Y C Kuo
Affiliations

Affiliation

  • 1 National Research Institute of Chinese Medicine, Pettou, Taipei 112, Taiwan, Republic of China. lclin@cma23.nricm.edu.tw
Abstract

Three new Anthraquinones, islandicin 4-methyl ether (1), 1,2,6-trihydroxy-7,8-dimethoxy-3-methylanthraquinone (2), and 2-hydroxyemodin 1-methyl ether (3) as well as two known triterpenoids [taraxerol (4), lupeol (5)], six Anthraquinones [chrysophanol (6), islandicin (8), parietin (9), emodin (10), catenarin (11), skyrin (15)], a 2,3-dihydroflavonol [(+)-aromadendrin (12)], two benzisochromanquinones [ventiloquinone K (13) and ventiloquinone I (14)], and stigmasterol (7) were isolated from Ventilago leiocarpa. The cytotoxicity of these compounds to various tumor cell lines was evaluated, and compound 15 significantly suppressed growth of HeLa, Vero, K562, Raji, Wish, and Calu-1 tumor cell lines. With the exception of K562 cells, the proliferation of other tumor cell lines was inhibited by compounds 3 and 10.

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