2. Academic Validation
  3. Synthesis of polyamine derivatives having non-hypotensive Ca2 +-permeable AMPA receptor antagonist activity

Synthesis of polyamine derivatives having non-hypotensive Ca2 +-permeable AMPA receptor antagonist activity

  • Bioorg Med Chem Lett. 2001 May 21;11(10):1261-4. doi: 10.1016/s0960-894x(01)00170-6.
Y Yoneda 1,  S Kawajiri,  A Hasegawa,  F Kito,  S Katano,  E Takano,  T Mimura
Affiliations

Affiliation

  • 1 Medicinal Chemistry Research Laboratory, Daiichi Pharmaceutical Co, Ltd, Tokyo, Japan. yonedL0z@daiichipharm.co.jp
PMID: 11392532 DOI: 10.1016/s0960-894x(01)00170-6
Abstract

In order to obtain non-hypotensive and Ca2+-permeable AMPA Receptor antagonists, we have synthesized a series of 1,4-bis(4-piperidinylmethyl)diaminobutanes. Compounds 13b, c, f had desirable properties.

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